Uric Acid

Uric acid is the end product of purine metabolism in the human body, it is found in small amounts in urine, and is poorly soluble in water. Purine precursors include xanthine and hypoxanthine, which are converted to uric acid by xanthine oxidase, which is found in the liver. Finding xanthine oxidase in the blood would indicate liver disease. Humans produce only small quantities of uric acid with excess accumulation leading to a type of arthritis known as gout.In human blood, uric acid concentrations between 3.6 and 8.3 mg/dL are considered normal , although significantly lower levels are common in vegetarians  Vegetarian Diet due to a decreased intake of purine-rich meat.Gout Diet

Of the uric acid produced daily, the biliary and gastrointestinal tracts excrete 30% and the kidney excretes 70%. Renal excretion of uric acid involves 4 pathways—filtration, reabsorption, secretion, and postsecretory reabsorption.the major factors that affect urate excretion are the tubular fluid pH, tubular fluid flow rate, and renal blood flow. The first 2 pathways diminish uric acid and urate precipitation in the collecting ducts, while the third is important in urate secretion. Overproduction of uric acid occurs mostly when tissue breakdown is accelerated,this can occur as a result of chemotherapy , radiation therapy, or crash dieting.

Reference:McCance, Kathryn RN.PhD & Huether, Sue E.RN,PhD Pathophysiology. Published: The C.V.Mosby Company 1990.

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